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Adipex Review:

This page covers the mechanism of action, efficacy, indications, side effects, dosage and administration of the prescription weight loss drug Adipex.

The active ingredient in Adipex is Phentermine, an appetite suppressant of the amphetamine class, indicated for short-term use in the treatment of obesity in conjunction with diet and exercise.

Phentermine, a powerful central nervous system stimulant, is quite likely the most commonly prescribed weight loss agent in the United States. It is marketed under many different brand names, including Adipex P (immediate release formula), Anoxine-AM, Ionamine (slow release formula, discontinued in the US), Obenix, Oby-Trim, Obephen, Obestin-30, Phentrol, Phenterex, Phentromin, Pro-Fast SA, etc.

Adipex Review
Who should consider taking this medication?

  • Adipex (Phentermine) is not for everyone. It is reserved for obese patients whose health is at risk because of their weight.
  • So, if you have reached the threshold of obesity or surpassed it (BMI 30 or above), despite previous attempts at diet and/or exercise, then prescription weight loss medication is in order, and Adipex is a reasonable short-term choice.

You may use our BMI calculator to determine your BMI.

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Adipex Review
Efficacy and Mechanism of Action:

  • Phentermine (the active ingredient in Adipex) is a potent central nervous system stimulant, with proven clinical efficacy as far as promoting weight loss.
  • It works by increasing the amount of certain neurotransmitters in the brain (in particular Dopamine, Norepinephrine and Epinephrine), which in turn leads to appetite suppression.
  • This agent carries some risk of physical dependency, therefore it is only prescribed for short periods of time (up to 12 weeks).

Dosage and Administration:

  • Adipex is usually taken once a day, on an empty stomach, either half an hour before breakfast, or 2 hours after breakfast.
  • One dose can suppress appetite up to 12-14 hours.
  • This drug should not be taken in the evening, as it may cause insomnia.

Adipex Review
Side Effects:

Adipex can be habit forming, and needs to be taken under close medical supervision. The usual duration of treatment is 3-6 weeks, but may occasionally be extended up to 12 weeks.

Besides the risk of dependency mentioned above, other potential side effects are:
  • dry mouth and throat
  • nervousness and irritability
  • jitteriness, restlessness, and anxiety
  • insomnia
  • nausea or vomiting
  • change in bowel habits (either diarrhea or constipation)
  • menstrual pains
  • excessive sweating
More serious side effects include:
  • rapid or irregular heart rate
  • increased blood pressure
  • palpitations
  • headaches
  • dizziness or fainting
  • shortness of breath
  • leg swelling
  • chest pains or chest discomfort

If experiencing any of these side effects, notify your physician immediately.

Adipex Review
Important Warnings:

  • Adipex should not be taken in combination with monoamine oxidase (MAO) inhibitors, as this can cause severe hypertension.
  • Other medications acting on the central nervous system may compound the action of Adipex, leading to potentially dangerous side effects. Alcohol should be avoided during treatment with Adipex.
  • This medication is not indicated for women who are pregnant or breast-feeding.
  • Since Adipex may cause dry mouth, special attention should be given to oral hygiene to prevent gum disease.


Please note: Adipex is contraindicated in persons suffering from certain medical conditions such as severe high blood pressure, overactive thyroid, diseases of the heart and blood vessels, glaucoma, irregular or rapid heart rate, certain psychiatric conditions or a history of substance abuse. Only your doctor can determine if Adipex is right for you. A thorough medical checkup is advisable prior to starting this medication. At any time during treatment, should you experience any health problems perceived to be of a serious or urgent nature, please seek the services of an emergency medical provider.

Disclaimer: Although the information on this page is correct to the best of our knowledge, its accuracy and completion are not guaranteed. Prior to using this or any other weight loss medication, please discuss all your concerns with the physician prescribing the medication.

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