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How Effective Is It ?

Cytodine, the makers of Xenadrine, refer to Xenadrine NRG "as the next generation in energy and weight loss products". According to them, the product starts acting in 30 minutes and continues providing increased energy levels (i.e., accelerating metabolism and fat-burning processes) for up to 8 hours.

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Here's a list of the main ingredients in Xenadrine NRG:

  • Citrus Aurantium (bitter orange) extract, with its active ingredient Synephrine - a metabolic stimulant believed to have fat-burning properties similar to Ephedrine, but reportedly less cardiovascular risk
  • Yerba Mate - a central nervous system stimulant standardized for caffeine
  • Tyrosine - an aminoacid which promotes proper thyroid function
  • Phenylethylamine - a mood and energy enhancer
  • Green Tea extract with thermogenic and antioxidant properties
  • Vitamins B and C
  • Norambrolide - which is fermented Salvia Sclarea leaf extract

At first glance, you can see that the formula of Xenadrine NRG appears very similar to that of Xenadrine EFX: However, there is one notable addition, namely the compound called Norambrolide (fermented Salvia Sclarea). This substance is a potent adenylate cyclase activator, meaning it activates the enzyme which transforms ATP to cyclic AMP. In turn, cyclic AMP increases the breakdown of fat.

Efficacy and Side Effects:

Overall, Xenadrine NRG appears to be targeting the fitness-oriented public and body builders, rather than the overweight individual looking to shed the pounds. Although in theory this formula may have potential, there is insufficient clinical data at this time to support the efficacy of the new compound Norambrolide for weight loss.

As with Xenadrine EFX, the combination of stimulant agents in Xenadrine NRG is worrisome from the point of view of potential side effects. Possible reactions to this drug include restlessness, jitteriness, irritability, headaches, insomnia, excessive sweating, dizziness, faintness, nausea, upset stomach, cramping and diarrhea, as well as cardiovascular effects such as increased blood pressure and heart rate. (This should constitute a warning for individuals with cardiovascular disease or cardiovascular risk factors.)

From the customer reviews I have read online so far, I was struck by the high number of people reporting side effects, versus the low number reporting any tangible weight loss benefit.


The recommended dose is 2 tablets per day, which can later be increased to 3 tablets per day.


Availability: Xenadrine NRG may be purchased online from various retailers, with prices ranging between $25 and $40 for 120 pills.


Please note: This product is for the use of adults only. Pregnant or nursing women should not take this product. Please be aware that any weight loss supplement may be associated with certain side effects and/or health risks. It is prudent to talk to your physician prior to using this or any other weight loss product, especially if you are taking other medication or suffer from a preexisting medical condition.

Disclaimer: Although the information on this page is correct to the best of our knowledge, its accuracy and completion are not guaranteed. Prior to using this or any other weight loss supplement, please refer to the instructions included by the manufacturer with the product purchased.

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